Benign Sinonasal Neoplasms

Benign Sinonasal Neoplasms

Module Summary

Benign sinonasal neoplasms represent a diverse group of pathologic entities. The most commonly associated symptoms include nasal obstruction, rhinorrhea, epistaxis, or facial pressure/pain. Comprehensive evaluation begins with a thorough history, physical exam, and nasal endoscopy followed by imaging. CT is typically utilized as the primary imaging modality; however, MRI can offer complimentary information in select cases. Biopsy provides diagnostic information and can aide in treatment planning. Endoscopic surgery is the mainstay of current therapy, whereas open and endoscopic-assisted procedures (hybrid), although utilized, are less common.

Inverted papilloma represents a unique, benign, sinonasal neoplasm that has malignant potential. Associations with HPV, as well as risk factors for malignant transformation, are being actively studied. The evaluation is similar too other benign sinonasal neoplasms. Thorough endoscopic surgery with careful attention to, and removal of, the attachment site is the most commonly accepted treatment modality currently. Recurrence of inverted papilloma is possible and potential risk factors have been described. Post-surgical surveillance is important.

JNA represents a benign but locally aggressive vascular neoplasm found almost exclusively in adolescent males. Given its vascular origins special considerations in evaluation and management exist. These tumors can have intracranial extension and therefore both CT and MRI are often performed in the evaluation. Most patients undergo angiography with pre-operative embolization prior to surgical resection. Many of these tumors can be resected with endoscopic techniques.

Module Learning Objectives 
  1. Describe the various types of benign sinonasal neoplasms.
  2. Explain the comprehensive evaluation of a sinonasal neoplasm.
  3. Discuss the role of imaging (i.e., CT and/or MRI) in the diagnostic evaluation of sinonasal neoplasms.
  4. Explain the unique pathogenesis and biology of inverted papilloma.
  5. Distinguish inverted papilloma from other benign sinonasal neoplasms.
  6. Describe the risk of malignancy of inverted papilloma.
  7. Discuss the evaluation and management of JNA.
  8. Distinguish between encephalocele, glioma, and dermoid lesions.
  9. Explain options in management of benign neoplasms.
  10. Differentiate options in surgical management between inverted papilloma and other benign sinonasal neoplasms.

Pathogenesis

Learning Objectives 
  1. Describe the common types of benign sinonasal neoplasms.
    1. Sinonasal Papilloma
      1. Oncocytic
      2. Exophytics
      3. Inverted
    2. Osseous and Fibro-Osseous Tumors
      1. Osteoma
      2. Fibrous Dysplasia
      3. Ossifying Fibroma
    3. Mesenchymal (vascular) Neoplasms
      1. Pyogenic Granuloma
      2. Sinonasal Hemangiopericytoma (glomangiopericytoma)
      3. Juvenile Nasopharyngeal Angiofibroma (JNA)
      4. Solitary fibrous tumor
    4. Meningothelial
      1. Meningioma
  2. Discuss the possible role of inflammation and HPV in the pathogenesis of inverted papilloma.
  3. Distinguish inverted papilloma as a unique benign sinonasal neoplasm with malignant potential.
  4. Describe the diagnosis and evaluation of JNA.
  5. Distinguish between encephalocele, dermoid, and glioma.
  6. Describe osteomas of the sinuses.
References 
  1. Hennessey PT, Reh DD. Benign Sinonasal Neoplasms. Am J Rhinol Allergy. 2013;27:S31-34.
  2. Melroy CT, Senior BA. Benign Sinonasal Neoplasms: A focus on inverting papilloma. Otolaryngol Clin North Am. 2006;39:601-617.
  3. Thompson LDR, Fanburg-Smith JC. Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions. Head and Neck Pathol. 2016;10:95-108.
  4. Roh HJ, Procop GW, Batra PS, et al. Inflammation and the pathogenesis of inverted papilloma. Am J Rhinol. 2004;18:65-74.
  5. Syrjanen KJ. HPV infections in benign and malignant sinonasal lesions. J Clin Pathol. 2003;56:174-181.
  6. Levine HL, Weinstein MA, Tucker HM, Wood BG, Duchesneau PM. Diagnosis of juvenile nasopharyngeal angiofibroma by computed tomography. Otolaryngol Head Neck Surg. 1979;87(May-June):304-310.
  7. Antonelli AR, Capiello J, Lorenzo DD, Donajo CA, Nicolai P, Orlandini A. Diagnosis, staging, and treatment of juvenile nasopharyngeal angiofibroma (JNA). Laryngoscope. 1987;97:1319-1325.
  8. Duvall AJ, Moreano AE. Juvenile nasopharyngeal angiofibroma: diagnosis and treatment. Otolaryngol Head Neck Surg. 1987;97:534-540.
  9. Van Wyhe RD, Chamata ES, Hollier LH. Midline craniofacial masses in children. Semin Plast Surg. 2016;Nov,30(4):176-180.
  10. Georgalas C, Goudakos J, Fokkens WJ. Osteoma of the skull base and sinuses. Otolaryngol Clin North Am. 2011;Aug,44(4):875-90.

Basic Science

Learning Objectives 
  1. Be familiar with the possible associations of HPV subtypes in sinonasal papillomas.
    1. HPV 6, 11, 16, & 18
  2. Be familiar with the association of HPV and risk malignant transformation in inverted papilloma.
References 

Incidence

Learning Objectives 
  1. Be familiar with occupational exposures and the possible risk of developing inverted papilloma.
  2. Recognize the incidence of malignancy in inverted papilloma.
References 
  1. D’Errico A, Zajacova J, Cacciatore A, Baratti A, Zanelli R, Alfonzo S, Beatrice F. Occupational risk factors for sinonasal inverted papilloma: a case-control study. Occup Environ Med. 2013;70:703-708.
  2. Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS. Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. The Journal of Laryngology & Otology. 2007;121:857-864.
  3. von Buchwald C, Bradley PJ. Risks of malignancy in inverted papilloma of the nose and paranasal sinuses. Curr Opin Otolaryngol Head Neck Surg. 2007;15:95-98.

Genetics

Learning Objectives 
  1. Be familiar with the cytogenetics and molecular genetics of sinonasal inverted papilloma.
  2. Be familiar with the molecular profile of JNA.
References 
  1. Sauter A, Matharu R, Hormann K, Naim R. Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review). Oncology Reports. 2007;17:495-504.
  2. Pandey P, Mishra A, Tripathi AM, et al. Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India. Laryngoscope. 2017;Mar,127(3):E100-106.

Patient Evaluation

Learning Objectives 
  1. Discuss the evaluation of a patient with a benign sinonasal neoplasm.
References 
  1. Melroy CT, Senior BA. Benign Sinonasal Neoplasms: A focus on Inverting Papilloma. Otolaryngol Clin N Am. 2006;39:601-617.

Measurement of Functional Status

Learning Objectives 
  1. Describe the impact endoscopic surgery for sinonasal neoplasms has on quality-of-life metrics.
References 
  1. Deckard NA, Harrow BR, Barnett SL, Batra PS. Comparitive analysis of quality-of-life metrics after endoscopic surgery for sinonasal neoplasms. Am J Rhinol Allergy. 2015;29:151-155.

Imaging

Learning Objectives 
  1. Describe the role of imaging in the evaluation of sinonasal neoplasms.
  2. Be familiar with imaging characteristics of various sinonasal tumors.
  3. Describe the imaging characteristics of JNA including the Hollman-Miller sign.
  4. Describe the role of angiography and embolization in the management of JNA.
  5. Be familiar with the various options of transarterial or intratumoral embolization in JNA.
References 
  1. Eggesbo HB. Imaging of sinonasal tumors. Cancer Imaging. 2012;12:136-152.
  2. Koeller KK. Radiologic Features of Sinonasal Tumors. Head Neck Pathol. 2016;10(1):1-12.
  3. Janakiram TN, Sharma SB, Samavedam UC, Deshmukh O, Rajalingam B. Imaging in Juvenile Nasopharyngeal angiofibroma: Clinical significance of Ramharan and Chopstick sign. Indian J Otolaryngol Head Neck Surg. 2017;Mar,69(1):81-87.
  4. Ballah D, Rabinowitz D, Vossough A, Rickert S, Dunham B, Kazahaya K, Cahill AM. Preoperative angiography and external carotid artery embolization of juvenile nasopharyngeal angiofibromas in a tertiary referral paediatric centre. Clin Radiology. 2013;68:1097-1106.
  5. Wu AW, Mowry SE, Vinuela F, Abemayor E, Wang MB. Bilateral vascular supply in juvenile nasopharyngeal angiofibroma. Laryngoscope. 2011;121:639-643.
  6. Lv MM, Fan X, Chen D. Preoperative direct puncture embolization of advanced juvenile nasopharyngeal angiofibroma in combination with transarterial embolization: an analysis of 22 consecutive patients. Cardiovasc Intervent Radiol. 2013;36:111-117.

Pathology

Learning Objectives 
  1. Be familiar with the histopathology of various benign sinonasal neoplasms.
  2. Describe the histopathologic findings that occur with inverted papilloma.
  3. Be familiar with possible growth factor and hormonal associations with JNA.
References 
  1. Thompson LDR, Fanburg-Smith JC. Update on select benign mesenchymal and meningothelial sinonasal tract lesions. Head and Neck Pathol. 2016;10:95-108.
  2. Chiu AG, Jackman AH, Antunes MB, et al. Radiographic and histologic analysis of the bone underlying inverted papillomas. Laryngoscope. 2006;116:1617-1620.
  3. Bishop JA. OSPs and ESPs and ISPs, Oh My! An Update on Sinonasal (Schneiderian) Papillomas. Head and Neck Pathol. 2017 Sep;11(3):269-277
  4. Liu Z, Wang J, Wang H, Wang D, Hu L, Liu Q, Sun X. Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis. Acta Otolaryngol. 2015;Jan,135(1):51-7.
  5. Patel ZM, Lin FY eds. ENT Board Prep High Yield Review for the Otolaryngology Inservice and Board Exams. Springer, New York, NY. 2013.

Treatment

Learning Objectives 
  1. Be familiar with guidelines and options in management of sinonasal neoplasms.
  2. Discuss the management options for inverted papilloma.
  3. Discuss the options in treatment of JNA.
  4. Be familiar with the role of radiation as a treatment option in the management of JNA.
References 
  1. Lund VJ, Clarke PM, Swift AC, McGarry GW, Kerawala C, Carnell D. Nose and paranasal sinus tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016 May;130(S2):S111-S118.
  2. Attlmayer B, Derbyshire SG, Kasbekar AV, Swift AC. Management of inverted papilloma: review. J Laryngol Otol. 2017 Apr;131(4):284-289.
  3. Lawson W, Patel ZM. The evolution of management for inverted papilloma: an analysis of 200 cases. Otolaryngol Head Neck Surg. 2009 Mar;140(3):330-5.
  4. Boghani Z, Husain Q, Kanumuri VV, Khan MN, Sangvhi S, Liu JK, Eloy JA. Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. Laryngoscope. 2013;123:859-869.
  5. Reddy KA, Mendenhall WM, Amdur RJ, Stringer SP, Cassisi NJ. Long-term results of radiation therapy for juvenile nasopharyngeal angiofibroma. Am J Otolaryngol. 2001;22:172-175.
  6. Lee JT, Chen P, Safa A, Juillard G, Calcaterra TC. The Role of Radiation in the Treatment of Advanced Juvenile Angiofibroma. Laryngoscope. 2002;112:1213-1220.
  7. McAfee WJ, Morris CG, Amdur RJ, Werning JW, Mendenhall WM. Definitive Radiotherapy for Juvenile Nasopharyngeal Angiofibroma. American Journal of Clinical Oncology. 2006;29(2):168-170.

Surgical Therapies

Learning Objectives 
  1. Describe surgical principles in the endoscopic removal of benign sinonasal tumors.
  2. Discuss the risks and safety considerations of surgery for inverted papilloma.
  3. Be familiar with the special considerations of endoscopic sinus surgery in the management of inverted papilloma.
    1. Open vs closed
    2. Attachment site removal
  4. Describe the clinical outcomes of surgery for inverted papilloma.
  5. Describe the surgical options in the treatment of JNA.
  6. Discuss endoscopic surgery options in the treatment of JNA.
  7. Distinguish surgical outcomes of JNA with intracranial involvement.
References 
  1. Harvey RJ, Sheahan PO, Schlosser RJ. Surgical Management of Benign Sinonasal Masses. Otolaryngol Clin N Am. 2009;42:353-375.
  2. Krouse JH. Endoscopic Treatment of Inverted Papilloma: Safety and Efficacy. Am J Otolaryngol. 2001;22(2):87-99.
  3. Reh DD, Lane AP. The role of endoscopic sinus surgery in the management of sinonasal inverted papilloma. Curr Opin Otolaryngol Head Neck Surg. 2009 Feb;17(1):6-10.
  4. Busquets JM, Hwang PH. Endoscopic Resection of Sinonasal Inverted Papilloma: A Meta-analysis. Otolaryngol Head Neck Surg. 2006;134:476-482.
  5. Lawson W, Patel ZM. The evolution of management for inverted papilloma: An analysis of 200 cases. Otolaryngol Head Neck Surg 2009;140:330-335.
  6. Woodworth BA, Bhargave GA, Palmer JN, et al. Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: A 15-year experience. Otolaryngol Head Neck Surg. 2006;134:476-482.
  7. Andrade NA, Pinto JA, Nobrega M, Aguiar JE, Aguiar TF, Vinhaes E. Exclusively endoscopic surgery for juvenile nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg 2007;137:492-496.
  8. Khoueir N, Nicolas N, Rohayem Z, Haddad A, Hamad WA. Exclusive endoscopic resection of juvenile nasopharyngeal angiofibroma: A systematic review of the literature. Otolaryngol Head Neck Surg. 2014;150(3):350-358.
  9. Zanation AM, Mitchell CA, Rose AS. Endoscopic Skull Base Techniques for Juvenile Nasopharyngeal Angiofibroma. Otolaryngol Clin N Am. 2012;45:711-730.
  10. Mattei TA, Nogueira GF, Ramina R. Juvenile nasopharyngeal angiofibroma with intracranial extension. Otolaryngol Head Neck Surg. 2011;145(3):498-504.
  11. Danesi G, Panciera DT, Harvey RJ, Agostinis C. Juvenile nasopharyngeal angiofibroma: Evaluation and surgical management of advanced disease. Otolaryngol Head Neck Surgery. 2008;138:581-586.
  12. Leong S. A Systematic Review of Surgical Outcomes for Advanced Juvenile Nasopharyngeal Angiofibroma with Intracranial Involvement. Laryngoscope. 2013;123:1125-1131.
  13. http://www.american-rhinologic.org/videos (Surgical dissection videos on the ARS website, for members. ARS membership is FREE for residents.)

Staging

Learning Objectives 
  1. Describe the currently available staging systems in use for inverted papilloma.
  2. Describe the currently available staging systems in use for JNA
References 
  1. Krouse JH. Development of a Staging System for Inverted Papilloma. Laryngsoscope. 2000;110:965-968.
  2. Cannady SB, Batra PS, Sautter NB, Roh HJ, Citardi MJ. New staging system for sinonasal inverted papilloma in the endoscopic era. Laryngoscope. 2007;117:1283-1287.
  3. Onerci M, Ogretmenoglu O, Yucel T. Juvenile nasopharyngeal angiofibroma: a revised staging system. Rhinology. 2006;44(1):39-45.
  4. Snyderman CH, Pant H, Carrau RI, Gardner P. A new endoscopic staging system for angiofibromas. Arch Otolaryngol Head Neck Surg. 2010;136(6):588-594.
  5. Rowan NR, Zwagerman NT, Heft-Neal ME, Gardner PA, Snyderman CH. Juvenile nasal angiofibromas: a comparison of modern staging systems in an endoscopic era. J Neurol Surg. B 2017;78:63-67.

Case Studies

  1. A 25-year-old female presents with a 3-month history of recurrent right sided nose bleeds. The bleeding lasts minutes, is described of moderate severity, and is controlled with anterior compression. She has no history of coagulopathy or blood thinning medications. She is not currently pregnant, but delivered a child ~6-months prior. Physical exam reveals a raised well circumscribed ~5 mm vascular appearing lesion of the right anterior nasal septum. What is the most likely diagnosis? What options in treatment exist? If surgery is elected, what options in technique are there?
  2. A 52-year-old male presents with an 8-month history of left sided nasal obstruction with intermittent self-limiting nose bleeds. He denies ophthalmologic or neurologic symptoms. He has no prior history of cancer and is a never smoker. Nasal endoscopy reveals a well mucosalized pink appearing mass filling the left nasal cavity. What options in imaging are available? When would you consider biopsy? If biopsy is performed and results return as inverted papilloma, what are your next steps in management? How would you surgically excise this lesion if it is contained to the nasal cavity and/or sinuses? What risks of recurrence or malignant transformation are there?

Complications

Learning Objectives 
  1. Describe the incidence of inverted papilloma recurrence following surgery.
  2. Be familiar with risk factors that potentially increase the risk of recurrence in inverted papilloma.
    1. Surgical technique
    2. Tobacco smoke
    3. HPV
  3. Be familiar with the potential operative complications in JNA surgery.
References 

Review

Review Questions 
  1. What are the types of benign nasal neoplasms?
  2. What typically benign sinonasal neoplasm has a risk for malignant transformation?
  3. What are the diagnostic tests used to evaluate these tumors and aide in making the diagnosis?
  4. What are the options in management of benign sinonasal tumors?
  5. What special considerations exist in the surgical management of inverted papilloma?