Allergic Rhinitis

Allergic Rhinitis

Module Learning Objectives 
  1. Explain the risk factors for developing allergic rhinitis and immunological factors driving the process.
  2. Summarize the symptoms of allergic rhinitis and be able to differentiate from nonallergic rhinitis.
  3. Recognize the physical exam findings of allergic rhinitis.
  4. Describe the natural history of disease.
  5. Review prevalence and economic burden of allergic rhinitis.

 

Anatomy

Learning Objectives 
  1. Recognize the physical exam findings associated with allergic rhinitis.
  2. Recognize the impact of allergic rhinitis on other areas in the head and neck: ear, mouth, throat, larynx, eyes.  

 

References 
  1. Small P, Keith P, Kim H.  Allergic rhinitis. Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):51 
  2. Lin, SY. Allergy Primer: Current Concepts in the Diagnosis and Management of Allergic Rhinitis. Int Forum Allergy Rhinol. 2014 Sep;4 Suppl 2:S17. 
  3. King HC, Mabry RL, Mabry CS. Interaction with the patient. in: Allergy in ENT Practice: A Basic Guide, NY: Thieme; 1998. p. 64-94.

Pathogenesis

Learning Objectives 
  1. Explain the risk factors for developing allergic rhinitis and immunological factors that drive the process.
  2. Review the basic immunological pathway of the type 1 (Th2) allergic response.
References 
  1. Matheson MC, Dharmage SC, Abramson MJ, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population- based cohort study. J Allergy Clin Immunol 2011; 128:816
  2. Lin, SY. Allergy Primer: Current Concepts in the Diagnosis and Management of Allergic Rhinitis. Int Forum Allergy Rhinol. 2014 Sep;4 Suppl 2:S17.
  3. Pawankar R, Mori A, Ozu C. Overview of the pathomechanisms of allergic rhinitis.  Asia Pac Allergy. 2011 Oct; 1(3): 157–167

Incidence

Learning Objectives 
  1. Cite the prevalence of allergic rhinitis and the economic burden of disease in the United States.
References 
  1. Bhattacharyya N. Incremental healthcare utilization and expenditures for allergic rhinitis in the United States. Laryngoscope. 2011 Sep;121(9):1830-3.
  2. Settipane RA. Demographics and epidemiology of allergic and nonallergic rhinitis. Allergy Asthma Proc 2001; 22:185.
  3. Singh K, Axelrod S, Bielory L. The epidemiology of ocular and nasal allergy in the United States,1988-1994. J Allergy Clin Immunol. 2010 Oct;126(4):778-783.e6.   
  4. Vandenplas O, Vinnikov D, Blanc PD, et al. Impact of Rhinitis on Work Productivity: A Systematic Review. J Allergy Clin Immunol Pract. 2018 Jul - Aug;6(4):1274-1286.e9.

Genetics

Learning Objectives 
  1. Recognize the hereditary factors related to allergic disease.
References 
  1. Lin, SY. Allergy Primer: Current Concepts in the Diagnosis and Management of Allergic Rhinitis. Int Forum Allergy Rhinol. 2014 Sep;4 Suppl 2:S17.  

Patient Evaluation

Learning Objectives 
  1. Describe the symptoms of allergic rhinitis and be able to differentiate from nonallergic rhinitis.
  2. Recognize the differences between seasonal and perennial allergic rhinitis.
  3. Describe the physical exam findings in the head and neck suggestive for allergic disease.  

 

References 
  1. Howarth PH. Allergic and nonallergic rhinitis. In: Middleton's allergy: Principles and practice, 6th ed, Adkinson NF, Yunginger JW, Busse WW, et al (Eds). St. Louis: Mosby; 2003. p.1391.
  2. Small P, Keith P, Kim H.  Allergic rhinitis. Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):51. 
  3. Ciprandi G, Cirillo I, Pistorio A. Persistent allergic rhinitis includes different pathophysiologic types. Laryngoscope. 2008 Mar;118(3):385-8.

Measurement of Functional Status

Learning Objectives 
  1. Recognize the impact of allergic disease on the daily function of children and adults.
  2. Review common measures used to assess disease control in allergic rhinitis: symptom questionnaires, medication usage, quality of life questionnaires.

 

Testing

  1. Cite the available methods for testing for allergic rhinitis and the clinical relevance of each test:
  • Percutaneous (prick) testing
  • Intradermal testing
  • Intradermal dilutional testing
  • IgE specific (In Vitro) testing
  • Nasal Cytology
  • Allergen challenge

 

 

References 
  1. Koinis-Mitchell D, Craig T, Esteban CA, Klein RB. Sleep and allergic disease: a summary of the literature and future directions for research. J Allergy Clin Immunol. 2012 Dec; 130(6): 1275–1281. 
  2. Blaiss M, Hammerby B, Robinson et al. The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents: A literature review.  Ann Allergy Asthma Immunol. 2018 Jul;121(1):43-52.e3. 
  3. Demoly P, Calderon, Casal T, et al. Assessment of disease control in allergic rhinitis. Clin Transl Allergy. 2013; 3:7.

 

Testing References:

  1. Lin, SY. Allergy Primer: Current Concepts in the Diagnosis and Management of Allergic Rhinitis. Int Forum Allergy Rhinol. 2014 Sep;4 Suppl 2:S17.  
  2. King HC, Mabry RL, Mabry CS. Testing methods for inhalant allergy, in Allergy in ENT Practice: A Basic Guide. NY: Thieme; 1998. p. 103-154.
  3. Rondón C, Campo P, Herrera R, et al. Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis. J Allergy Clin Immunol. 2011 Dec;128(6):1192-7. 
  4. Klimek L, von Bernus L, Pfaar O. [Local (exclusive) IgE production in the nasal mucosa. Evidence for local allergic rhinitis]. HNO. 2013 Mar;61(3):217-23.

 

 

 

Pathology

Learning Objectives 
  1. Describe the local response that takes place in the nasal tissue when exposed to an allergen.
  2. Explain the cell types seen on a sample of mucosa.

 

References 
  1. Gelardi M, Iannuzzi L, Quaranta N, et al. NASAL cytology: practical aspects and clinical relevance. Clin Exp Allergy. 2016 Jun;46(6):785-92.
  2. Christodoulopoulos P, Cameron L, Durham H, Hamid Q. Molecular pathology of allergic disease. II: Upper airway disease.  J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):211-23.

 

Case Studies

History and progression of allergic rhinitis:  4-year-old patient presents with symptoms of nasal congestion, rhinorrhea, snoring, and frequent throat clearing.  Parents report the child is in preschool and is exposed to many other children.  She has history of eczema starting at 12 months old and has had questionable food allergies.  Physical exam shows dark, puffy, lower eyelids, nasal crease, and mouth-breathing.  She also has a history of middle ear effusions for which she has had tympanostomy tubes.

Differential diagnosis in children include recurrent acute infectious rhinitis, chronic rhinosinusitis, and adenoid hypertrophy.  Allergic rhinitis is less common in young children less than 2 years old though clinically significant sensitization to indoor allergens may occur.  The most common indoor allergens include dust mites, pet danders, cockroaches, molds.  Sensitization to outdoor allergens is more common in children older than 4–6 years as it may take several seasons to get enough exposure.  Typically allergies peak in the early school and early adult years.  Older adults are less likely to develop new allergies.  

Atopic dermatitis is often the first step in the allergic march in which the child goes on to develop allergic rhinitis and asthma. Environmental controls should be emphasized.  Testing can define the causative allergens and could allow definitive immunotherapy if environmental controls and medications are not effective.  Immunotherapy can prevent the development of asthma.

Seasonal allergic rhinitis:  19-year-old male presents cough, causing awakenings at night and drowsiness during the day.  He also complains of chronic rhinorrhea and congestion that is worse at night.  His nasal congestion contributes to his difficulty sleeping. His schoolwork is suffering as is his social life.  He is worse in the spring and fall.  On physical exam, the patient’s eyes are injected and chemotic.  They area also itchy and watery.  Turbinates are congested and bluish. Family history includes sibling with asthma and eczema.  Mother with allergic rhinitis.

Seasonal symptoms are symptoms that occur a certain time of the year.  Typically, allergies to pollen usually present between March – September.  Though pollination periods are different in different geographical areas, usually tree pollens from March to mid-May, grass pollens from mid-May to July. Weed pollens from the end of June to early September.  

Patients with episodic symptoms may be more aware of the disability from them.  Based on the WHO classification, his symptoms would be regarded as moderate-severe since they cause sleep disturbance and difficulty with daily activities.Treatment with avoidance measures such as washing hair before bed, wearing allergy masks, and using air conditioning in the car may be helpful.  Non-sedating antihistamines can be used.  Steroid sprays should be used daily.  Topical antihistamine eye drops and nasal spray can also be effective.  Requirement for testing and immunotherapy is required if patient does not respond to medical management as symptoms are affecting his sleep and daily function.

Review

Review Questions 
  1. What are five risk factors associated with development of allergic rhinitis in children?  Does maternal smoking play a role?
  2. What cytokines are important in the late phase response?  Which of these cytokines is a switch factor for IgE production?  From what cell are the cytokines released?
  3. When comparing seasonal vs. perennial allergic rhinitis, in which is the patient more likely to experience more severe symptoms? Which type is more likely to respond to decongestants?
  4. In patients with a history of nonallergic rhinitis (NAR) what might you find in the nasal mucosa in response to an allergen challenge? 
  5. What is one of the most important sequaela of untreated allergic rhinitis?  What other areas does allergic rhinitis negatively impact in children and adults?