Acute Otitis Media and Complications

Acute Otitis Media and Complications

Module Summary

Acute otitis media is a common disease process, primarily seen in children. Since the introduction of vaccines, there has been a dramatic decrease in its complications, but the most common pathogens S. pneumoniae, H. influenza, and M. Catarrhalis continue to be prevalent. Treatment involves antibiotics and tympanostomy tubes, sometimes in conjunction with an adenoidectomy. Other treatment options such as steroids are controversial. Untreated acute otitis media can result in hearing loss and subsequent speech delay. However, some of its complications such as intracranial abscesses, mastoiditis, and facial paralysis, while rare, can result in serious morbidity. Timely identification and treatment are critical to limiting the morbidity and mortality of this common disease.

Module Learning Objectives 
  1. Acquire a thorough understanding of the pathogenesis of otitis media.
  2. Develop an evidence-based practice algorithm for the medical and surgical management of acute otitis media.
  3. Recognize and manage the complications of acute otitis media.

 

Anatomy

Learning Objectives 
  1. Review and describe the anatomy of the temporal bone and how middle ear air exchange through the eustachian tube and mastoid affects the development of middle ear disease.
References 
  1. Alper CM, Luntz M, Takahashi H, Ghadiali SN, Swarts JD, Teixeira MS, Csákányi Z, Yehudai N, Kania R, Poe DS. Panel 2: Anatomy (Eustachian Tube, Middle Ear, and Mastoid-Anatomy, Physiology, Pathophysiology, and Pathogenesis). Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S22-S40.

Pathogenesis

Learning Objectives 
  1. Explain how the anatomy of the eustachian tube contributes to otitis media.
  2. Recognize the contribution of adenoids to otitis media.

 

References 
  1. Bluestone CD, Doyle WJ. Anatomy and physiology of eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol. 1988 May;81(5 Pt 2):997-1003. 
  2. Skoloudik L, Kalfert D, Valenta T, Chrobok V. Relation between adenoid size and otitis media with effusion. Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Dec;135(6):399-402.

 

Basic Science

Learning Objectives 
  1. Recognize the role of biofilms in the development of recurrent acute otitis media.
  2. Discuss the role of allergy in otitis media.
  3. Review the molecular biology of otitis media and how they play a role in the inflammation and resolution of the disease.

 

References 
  1. Torretta S, Drago L, Marchisio P, Ibba T, Pignataro L. Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. J Clin Med. 2019 May 13;8(5). pii: E671.
  2. Zernotti ME, Pawankar R, Ansotegui I, Badellino H, Croce JS, Hossny E, Ebisawa M, Rosario N, Sanchez Borges M, Zhang Y, Zhang L. Otitis media with effusion and atopy: is there a causal relationship? World Allergy Organ J. 2017 Nov 14;10(1):37.
  3. LiJ -D., Hermansson A., Ryan A.F., Bakaletz L.O., brown S.D., Cheeseman M.T. Panel 4: recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head neck Surg. 2013;148:E52–E63.

 

Incidence

Learning Objectives 
  1. Cite the number of visits for otitis media in children yearly and the trends over time.
  2. Summarize the incidence of complications of acute otitis media presenting to the Emergency Departments.

 

References 
  1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.
  2. Ren Y, Sethi RKV, Stankovic KM. Acute Otitis Media and Associated Complications in United States Emergency Departments. Otol Neurotol. 2018 Sep;39(8):1005-1011.

 

Patient Evaluation

Learning Objectives 
  1. Describe the presentation of acute otitis media.
  2. List the various complications of acute otitis media and describe their presentation and associated findings.
References 
  1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.
  2. Mattos JL, Colman KL, Casselbrant ML, Chi DH. Intratemporal and intracranial complications of acute otitis media in a pediatric population. Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2161-4.
  3. Hutz MJ, Moore DM, Hotaling AJ. Neurological Complications of Acute and Chronic Otitis Media. Curr Neurol Neurosci Rep. 2018 Feb 14;18(3):11.

Measurement of Functional Status

Learning Objectives 
  1. Explain how different forms of audiometric testing can be used to assess the presence and severity of middle ear disease.

Imaging

Learning Objectives 
  1. Describe the indications for imaging and findings in acute otitis media and its common complications.
References 
  1. Pont E, Mazón M. Indications and radiological findings of acute otitis media and its complications. Acta Otorrinolaringol Esp. 2017 Jan - Feb;68(1):29-37.
  2. Marom T, Roth Y, Boaz M, Shushan S, Oron Y, Goldfarb A, Dalal I, Ovnat Tamir S. Acute Mastoiditis in Children: Necessity and Timing of Imaging. Pediatr Infect Dis J. 2016 Jan;35(1):30-4.

 

Pathology

Learning Objectives 
  1. Review the most common pathogens in acute otitis media.
References 
  1. Ngo CC, Massa HM, Thornton RB, Cripps AW. Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review. PLoS One. 2016 Mar 8;11(3):e0150949.
  2. Holder RC, Kirse DJ, Evans AK, Peters TR, Poehling KA, Swords WE, Reid SD. One third of middle ear effusions from children undergoing tympanostomy tube placement had multiple bacterial pathogens. BMC Pediatr. 2012 Jun 28;12:87.

 

Treatment

Learning Objectives 
  1. Review the clinical practice guidelines in the treatment of acute otitis media.
  2. Indicate when antibiotics are indicated in the treatment of acute otitis media.

 

References 
  1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.

Medical Therapies

Learning Objectives 
  1. Discuss the role of oral antibiotics for the treatment of acute otitis media.
  2. Review the efficacy or lack thereof of steroids in the role of treatment for acute otitis media.

 

References 
  1. Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilder AG. Antibiotics for otitis media with effusion in children. Cochrane Database Syst Rev. 2016 Jun 12;(6):CD009163.
  2. Simpson SA, Lewis R, van der Voort J, Butler CC. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. 2011 May 11;(5):CD001935.
  3. Francis N.A., Cannings-John R., Waldron C.A. Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial. Lancet. 2018;392:557–568.

 

Pharmacology

Learning Objectives 

See Medical Therapies. 

Surgical Therapies

Learning Objectives 
  1. Recognize when a tympanostomy tube is indicated for acute otitis media.
  2. Identify when a mastoidectomy is indicated in the presentation of mastoiditis or other complication of acute otitis media.
  3. Discuss the role of adenoidectomy for the treatment of otitis media.
  4. Discuss the role of mastoidectomy in setting of chronic otitis media.

 

References 
  1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.
  2. Ghadersohi S, Young NM, Smith-Bronstein V, Hoff S, Billings KR. Management of acute complicated mastoiditis at an urban, tertiary care pediatric hospital. Laryngoscope. 2017 Oct;127(10):2321-2327.
  3. Osborn AJ, Blaser S, Papsin BC. Decisions regarding intracranial complications from acute mastoiditis in children. Curr Opin Otolaryngol Head Neck Surg. 2011 Dec;19(6):478-85. 
  4. Ulanovski D, Yacobovich J, Kornreich L, Shkalim V, Raveh E. Pediatric otogenic sigmoid sinus thrombosis: 12-Year experience. Int J Pediatr Otorhinolaryngol. 2014 Jun;78(6):930-3.
  5. Boonacker C.W., Rovers M.M., Browning G.G., Hoes A.W., Schilder A.G., Burton M.J. Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis. Health Technol. Assess. 2014;18:1–118.
  6. Trinidade A, Page JC, Dornhoffer JL. Therapeutic Mastoidectomy in the Management of Noncholesteatomatous Chronic Otitis Media: Literature Review and Cost Analysis. Otolaryngol Head Neck Surg. 2016 Dec;155(6):914-922. Epub 2016 Aug 2.
  7. Eliades SJ, Limb CJ. The role of mastoidectomy in outcomes following tympanic membrane repair: a review. Laryngoscope. 2013 Jul;123(7):1787-802.

 

Rehabilitation

Learning Objectives 
  1. Recognize the impact of hearing loss from acute otitis media and understand when rehabilitation such as amplification and speech therapy is needed.
References 
  1. Welling DR, Ukstins CA. Otitis Media: Beyond the Examining Room. Pediatr Clin North Am. 2018 Feb;65(1):105-123.

Case Studies

  1. 5 year old presents with a 2 day history of left ear pain and fever of 101. Examination demonstrates an intact bulging opacified tympanic membrane. What do you do? One week later she returns, and the left ear is now protruding and she is tender over the mastoid. What is the next course of action? What imaging would you obtain?
  2. 2 year old presents with her 3rd ear infection in the past 9 months. How would you counsel the parents as to the management of her recurrent ear infections? What if the child were 4 years old and already had 2 sets of tubes previously? How would the counseling change?

 

References 
  1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.
  2. Marom T, Roth Y, Boaz M, Shushan S, Oron Y, Goldfarb A, Dalal I, Ovnat Tamir S. Acute Mastoiditis in Children: Necessity and Timing of Imaging. Pediatr Infect Dis J. 2016 Jan;35(1):30-4.
  3. Ghadersohi S, Young NM, Smith-Bronstein V, Hoff S, Billings KR. Management of acute complicated mastoiditis at an urban, tertiary care pediatric hospital. Laryngoscope. 2017 Oct;127(10):2321-2327.

 

Complications

Learning Objectives 
  1. List the complications of acute otitis media and describe the management for them.
References 
  1. Arts, HA, Adams ME. Intratemporal and Intracranial complications of Otitis Media. Chapter 149. In: Bailey’s Head and Neck Surgery Otolaryngology, 5th Edition. 2014. 2399-2409.

Review

Review Questions 
  1. What are the signs and symptoms of acute otitis media?
  2. What antibiotics are recommended for the treatment of acute otitis media?
  3. When are tympanostomy tubes indicated? When is an adenoidectomy indicated?
  4. What are the intracranial and extracranial complications of otitis media?

 

References 
  1. Johanna M. Uitti, Miia K. Laine, Paula A. Tähtinen, Olli Ruuskanen, Aino Ruohola. Symptoms and Otoscopic Signs in Bilateral and Unilateral Acute Otitis Media. Pediatrics, Feb 2013, 131 (2) e398-e405
  2. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99.
  3. Arts, HA, Adams ME. Intratemporal and Intracranial complications of Otitis Media. Chapter 149, In: Bailey’s Head and Neck Surgery Otolaryngology, 5th Edition. 2014. 2399-2409.