Granulomatous diseases of the larynx are generally relatively rare systemic diseases with manifestations in the larynx and other sites in the head and neck. When they affect the larynx, this can result in dysphonia and dyspnea, and less likely dysphagia. While common diseases have predilection for laryngeal subsites (with sarcoidosis generally involving the supraglottis, amyloidosis the glottis, and granulomatous with polyangiitis the subglottis), in practice each pathology can affect each subsite. At times the Otolaryngologist may be the first physician to diagnose the disease with serologic testing and/or tissue biopsy confirming clinical suspicion. Treatment is usually in collaboration with a Rheumatologist/Pulmonologist/Oncologist with the Otolaryngologist offering local therapies and laryngoscopic surveillance.